Tobias B. Huber University Medical Center Freiburg

Research Focus:

Our main research interests are in understanding the molecular mechanisms underlying glomerular disease. Specifically, our work identified signalling programs that regulate podocyte cell survival, endocytosis, cytoskeletal organization and polarity, providing novel insight of how podocytes contribute to glomerular diseases. Our latest research includes the study of mTor-autophagy signalling networks in glomerular disease and kidney aging. We are also coordinating NephAge, a collaborative systems biology program that is designed to identify and analyze the complex and dynamic interplay of factors that control glomerular disease.

Relevance of your Provisional grouping in KidneyConnect: 

  • Treating and preventing chronic glomerular diseases remains a major challenge in Nephrology. Within KidneyConnect we would like to provide a tool platform helping to elucidate the molecular signalling network involved in chronic glomerular diseases.
  • Resources Available relevant to your grouping
  • High throughput Podocyte isolation protocols allowing for proteomic analysis
  • Primary culture of transgenic podocytes
  • Complementary set of transgenic mice (including mTOR pathway, aging models, various slit diaphragm models).
  • Models organisms including Drosophila and C. elegans/ Genomwide Screens
  • Proteomic/Genomic/microRNA Expression datasets of freshly isolated podocytes
  • Systemsbiology platform for data analysis